Some drugs are secreted in breast milk. They are not required for the baby and may be harmful. Most drugs excreted in breast milk are less than 10% of the therapeutic dose in children. As a general rule, breastfeeding should not be done for 3 hours after taking a drug. 90% of patients with rheumatoid and other inflammatory arthritis suffer a disease flare within three months of delivery. It may be prudent to stop feeding the child early in case of need to start contraindicated drugs for patients with nonresponsive arthritis. It must be kept in mind that optimal disease control is essential for the prevention of deformities. A disabled mother, due to deformed joints, will undoubtedly be unable to bring up her child well.
Recommendations on the use of drugs during breastfeeding are given in the following table.
Drug | Remark | |
---|---|---|
1 |
Paracetamol |
Safe. Feed after 3 hours. |
2 |
Anti-inflammatory Painkillers |
Safe/no substantial information. Ibuprofen, Indomethacin, Diclofenac, and Naproxen are compatible. Ibuprofen is the best choice. |
3 |
Steroids |
No adverse effects on children up to 10 mg/day. Prednisone preferred, Less than 0.1%excreted in milk |
4 |
Hydroxychloroquin |
Safe. 2% of the dose excreted in milk |
5 |
Sulphasalazine |
Safe. Caution in premature babies and infantile jaundice. |
6 |
Methotrexate |
No reported risk. Less than 10% excreted in milk. Do not feed for 9 hours after tablet. Monitor the child. |
7 |
Leflunomide |
Insufficient data about secretion in milk. Avoid if possible. |
8 |
Azathioprine |
Safe. Almost undetectable in milk. No evidence of adverse effects in infants. Monitor the child. |
9 |
Cyclophosphamide |
No data. Avoid if possible. |
10 |
Mycophenolate |
Avoid. |
11 |
Tofacitinib |
Excreted in animal milk. Avoid. Not known whether excreted in human milk. |
12 |
Etanercept Infliximab Adalimumab |
Minimal excretion in breast milk. Compatible. |
13 |
Rituximab |
Insufficient data. Not recommended. |
14 |
Tocilizumab |
Insufficient data. Not recommended. |